The Effects of Estrogen on Artificial Endometrium

• Status: Completed
• Trial end date: 2018-09-01
• Target enrollment: 0
• Participant gender: Female

Summary

In this prospective randomized trial, the parameters of the frozen-thawed embryo transfer (FET) cycles were analyzed. This study was undertaken in the Department of Assisted Reproductive Technologies and Reproductive Genetics Center at Istanbul Memorial Hospital with approval of the local ethics committee. The aim of this prospective randomized clinical trial was to compare two methods of endometrial preparation for FET, oral estradiol and estradiol transdermal patch.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Memorial Sisli Hospital, Istanbul
• Treatments: Estradiol; Estradiol 17 beta-cypionate; Estradiol 3-benzoate; Estradiol valerate; Estrogens; Polyestradiol phosphate

Criteria

Inclusion Criteria:

• All the women with at least one day 5 or 6 blastocyst

• Appropriate endometrial thickness is more than 7 millimeters on the 14th day of artificial endometrial preparation cycle

• Age under 38 years

• Follicle stimulating hormone less than 12 IU/Liter

• No more than 2 previous treatment cycles

• No history of recurrent spontaneous abortions

Exclusion Criteria:

• Polycystic ovarian syndrome (> 30 cumulus oocyte complexes retrieved at the pick-up)

• Endocrine or metabolic disorder

• Endometriosis

• Embryos derived from donated gametes

• Any underlying diseases (kidney, liver or heart diseases)

• Bad-quality embryos

• Uterine malformation

• Endometrial polyp

• Severe male factor (Azoospermia)

• Body mass index more than 30

• Thrombophilia