The Effects of Different Long-acting Bronchodilator Medications on Asthma Patients With Different Genetic Variations
Status:
Terminated
Trial end date:
2011-09-01
Target enrollment:
Participant gender:
Summary
This study is looking at the effects of certain long-acting bronchodilators on patients with
asthma who have specific genetic variations. The investigators are interested in a certain
common genetic variation in the receptor for beta-agonists, which is found in as many of
one-sixth of the population. There is evidence that patients with asthma who have this
variation may not do as well when treated with albuterol on a regular basis. The
investigators will be looking at whether patients with this variation have more asthma
exacerbations over the course of a year when treated with salmeterol or formoterol, which are
long-acting forms of albuterol; and whether these patients have fewer exacerbations when
treated with tiotropium, which is a different long-acting bronchodilator that does not act at
this receptor. In both groups patients will also be receiving inhaled steroids.
Phase:
N/A
Details
Lead Sponsor:
Brigham and Women's Hospital
Collaborators:
Baim Institute for Clinical Research Harvard Clinical Research Institute Massachusetts General Hospital