The Effects of Diesel Exhaust Inhalation on Vascular Function - the Role of Endothelin

• Status: Completed
• Trial end date: 2008-05-01
• Target enrollment: 0
• Participant gender: Male

Summary

The purpose of this study is to identify the role of endothelin 1 (a natural vasoconstrictor) in the adverse vascular effects demonstrated after exposure to air pollution

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Edinburgh
• Collaborator: Umeå University
• Treatments: BQ 788; cyclo(Trp-Asp-Pro-Val-Leu); Endothelin Receptor Antagonists

Criteria

Inclusion Criteria:

• Healthy male volunteers

Exclusion Criteria:

• Use of regular medication

• Cigarette smoking

• Significant occupational exposure to air pollution

• Intercurrent illness