The Effects of Clonidine on the Diuretic Response in Cirrhotic Patients

• Status: Completed
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

To examine the effects of the addition of clonidine to diuretics on the mobilization of ascites at short-term (diuretic response and requirement of diuretics) and long-term (readmissions for tense ascites and requirement of diuretics) in cirrhotics with increased sympathetic nervous system. Secondary objectives were to study neuro-hormonal,hemodynamic effects and side effects of clonidine and diuretics.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: CHU de Charleroi
• Treatments: Clonidine; Diuretics

Criteria

Inclusion Criteria:

• Cirrhotic patients with ascites

• Plasma norepinephrine level > 300 pg/mL (normal value: 185 - 275 pg/mL)

Exclusion Criteria:

• Serum bilirubin concentration above 4.5 mg/dL

• Prothrombin time below 40%

• Platelet count below 40 X 10¨9/liter

• Serum creatinine concentration above 2 mg/dL

• Gastro-intestinal hemorrhage

• Alcoholic hepatitis

• Diabetes mellitus,

• Hepatocellular carcinoma

• Respiratory or cardiac failures

• Hepatic encephalopathy

• Bacterial infection