The Effects of Cannabis on Male Reproductive Functions
Status:
NOT_YET_RECRUITING
Trial end date:
2027-03-30
Target enrollment:
Participant gender:
Summary
The purpose of this study is to understand the direct effects of cannabis on male reproductive functions. The investigators plan to conduct a double-blind, placebo-controlled clinical trial to examine both the chronic and acute effects of cannabis use on male reproductive functions. Specifically, the investigators will examine the dose-dependent effects of acute cannabis use on male reproductive parameters, including sperm counts, motility, morphology, and testosterone levels, as well as sperm epimutations.
Participants \[cannabis users will be randomly assigned to 1) non-vaping, 2) placebo (vaping without cannabis), and 2 doses of cannabis, 3) 20 and 4) 40mg of THC in cannabis flower obtained from the NIDA drug supply\], and 5) non-cannabis users (nave control, no cannabis or placebo exposure).
Participants will provide surveys (cannabis use and sexual functioning and satisfaction etc.), peripheral blood, and semen.