The Effects of Caffeine Withdrawal on Migraine

• Status: Terminated
• Trial end date: 2019-07-22
• Target enrollment: 0
• Participant gender: All

Summary

Sporadic and chronic dietary consumption of caffeine has substantial biological effects on the nervous system. The effects on migraine are at large not known. In this study we want to assess the effects of caffeine withdrawal on migraine.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Nordlandssykehuset HF
• Collaborators: King's College London; University Hospital of North Norway
• Treatments: Caffeine

Criteria

Inclusion Criteria:

• migraine present for at least 1 year and fulfilling diagnostic criteria (ICHD-3 beta)

• =/> 3 migraine attacks per month

• no migraine prophylaxis the last month

• consumption =/> 300 mg and
• signed consent

Exclusion Criteria:

• suspicion of medication-overuse headache

• pregnancy and breast feeding

• serious co-morbidity or conditions requiring Medical treatment or caution

• working night shift

• use of drugs with moderate or major interactions with caffeine