The Effects of COX-inhibiting Drugs on Skeletal Muscle Adaptations to Resistance Exercise in Healthy Adults
Status:
Completed
Trial end date:
2016-06-01
Target enrollment:
Participant gender:
Summary
In this study, healthy human subjects (18-35 yrs) are be randomised to consume 1200 mg
ibuprofen or 75 mg acetylsalicylic acid daily during a training period of 8 weeks. During
these weeks, subjects perform 2-3 supervised strength training sessions (knee extensions).
Before and after training, muscle volume is measured by MRI, and muscle strength is assessed
by isokinetic and isoinertial ergometers. Muscle biopsies are obtained from m. vastus
lateralis to study gene and protein expression of markers regulating muscle protein turnover
and prostaglandin synthesis.