The Effects of Atorvastatin on the Nitric Oxide-system in Healthy Young Man

• Status: Completed
• Trial end date: 2011-06-01
• Target enrollment: 0
• Participant gender: All

Summary

It has been documented that statin reduce mortality and morbidity in patients with cardiovascular disease. This effect can partly be related to a reduction in cholesterol levels in blood. Nitric oxide (NO) production is reduced in several chronic diseases such as nephropathy, diabetes and hypertension. The purpose of this study is to investigate the effect of Atorvastatin treatment on the NO-system measuring renal and cardiovascular variables in healthy man.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Regional Hospital Holstebro
• Treatments: Atorvastatin; Atorvastatin Calcium; Nitric Oxide

Criteria

Inclusion Criteria:

• Men and women, age 18-40 years

• Body Mass Index (BMI) 18,5-30 kg/m2

Exclusion Criteria:

• Arterial hypertension (>140 mmHg systolic and/or 90 mmHg diastolic)

• Anamnestic or clinical signs of heart, lung, lever, kidney and brain disease

• Neoplastic disease

• Alcohol abuse,

• Drug abuse

• Medical treatment except oral anticontraceptive

• Smoking

• Pregnancy or

• Abnormal blood and urine sample

• Abnormal ECG

• Blood donation within a month before examination