The Effects of Atorvastatin Treatment in COPD Patients
Status:
Completed
Trial end date:
2013-04-01
Target enrollment:
Participant gender:
Summary
Rationale: Retrospective studies suggest that statins improve outcomes in COPD patients
possibly as a result of an anti-inflammatory effect.
Objectives: To determine whether statins have an anti-inflammatory effect on the lungs of
patients with COPD.
A controlled, parallel group study to compare the effects of Atorvastatin in comparison to
placebo as an add-on treatment to Formoterol therapy in patients with mild to moderate COPD
in group of 20 patients. All subjects will have spirometry, lung volumes, DLCO, SGRQ, 6MWD,
serum lipids and hs-CRP measured before and after treatment. Bronchoscopy and transbronchial
lung biopsy (TBB) will be carried out at baseline and after 12 weeks of treatment, and TBB
specimens will be processed for histology, immunohistochemistry and microarray analysis.