The Effects of Apomorphine on Experimental and Clinical Pain in Patients With Chronic Radicular Pain

• Status: Completed
• Trial end date: 2014-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The study aimed to explore the effect of the dopamine agonist apomorphine on spontaneous pain intensity and evoked cold clinical and experimental pain in patients with lumbar radicular neuropathic pain (NP). Patients received either apomorphine or placebo in a randomized double-blinded manner.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Rambam Health Care Campus
• Treatments: Apomorphine

Criteria

Inclusion Criteria:

1. Presence of radicular pain for at least 3 months;

2. Average pain level during the last week prior to enrollment > 40 (0-100);

3. No use of a new analgesic drug within 30 days prior to entry to the study and

4. Adults who were capable of understanding the purpose and instructions of the study and signing an informed consent.

Exclusion Criteria:

1. Pregnancy or breastfeeding;

2. Presence of Parkinson's disease or any other extra-pyramidal diseases;

3. History of allergy to the investigational drugs: Apomorphine or Domperidone;

4. History of polyneuropathy and

5. Respiratory depression, dementia, psychotic diseases or hepatic insufficiency