The Effects of Anti-HIV Drugs in HIV-Infected Patients Who Do Not Have AIDS
Status:
Completed
Trial end date:
2002-06-01
Target enrollment:
Participant gender:
Summary
Immunopathogenesis objectives: To compare and quantitatively determine HIV burden and HIV
replication in peripheral blood (PB) and lymphoid tissue (LT). To determine the degree to
which antiretroviral therapy alters HIV replication in LT.
Clinical objectives: To gain insight into the degree of correlation between immunologic
surrogate markers for HIV disease (e.g., CD4, beta-2 microglobulin) as compared to measures
of HIV replication in PB and LT. To assess changes in PB and LT viral burden after
antiretroviral therapy and to determine its ability to predict an antiviral response.
One of the major problems in defining the immunopathogenic changes in HIV infections has been
the inability to correlate the extent of loss of immunologic function with the number of
HIV-infected CD4+ cells in the peripheral blood. Few studies exist that measure viral burden
in lymph nodes of HIV-infected individuals. Researchers hope to find out whether the amount
of HIV virus or markers for the virus in the body's lymph tissue is a better measure of
disease progression than the amount of virus or markers for the virus in the blood.
Phase:
N/A
Details
Lead Sponsor:
National Institute of Allergy and Infectious Diseases (NIAID)