The Effects of Amiloride and Spironolactone on Renophysiological and Cardiovascular Variables

• Status: Completed
• Trial end date: 2015-08-01
• Target enrollment: 0
• Participant gender: All

Summary

The investigators wish to study the effect of retaining potassium. The participants have essential hypertension. The test substances are Amiloride, Spironolactone and placebo. The participants will ingest tablets for 28 days before being examined. We will perform a 24 hours urine collection, 24-hours bloodpressure measurement, blood and urine samples and we also examine the patient using a SphygmoCor.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Regional Hospital Holstebro
• Treatments: Amiloride; Spironolactone

Criteria

Inclusion Criteria:

• hypertension,

• BMI 18,5-30,

• non-smoker

Exclusion Criteria:

• Smoking

• Not using contraceptives

• Other illnesses

• Drug or alcohol abuse