Overview

The Effects of AZT and Ibuprofen on HIV-Infected Patients With Hemophilia

Status:
Completed
Trial end date:
1969-12-31
Target enrollment:
0
Participant gender:
All
Summary
To determine if platelet dysfunction and/or pharmacologic drug interaction occurs in patients taking both AZT and ibuprofen, which might account for enhanced bleeding tendency.
Phase:
N/A
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
University of Pittsburgh
Treatments:
Ibuprofen
Zidovudine
Criteria
Inclusion Criteria

Patients must have:

- Hemophilia.

- HIV-seropositivity confirmed by Western Blot.

Prior Medication:

Required:

- AZT for study patients.

Allowed:

- Ibuprofen.

Exclusion Criteria

Co-existing Condition:

Patients with the following symptoms and conditions are excluded:

Hospitalization for opportunistic infection, bacterial infection or malignancy.

Concurrent Medication:

Excluded:

- AZT (for control group).

- Antibiotics or other medication for opportunistic infection, bacterial infection, or
malignancy.

Patients with the following prior conditions are excluded:

Hospitalization for opportunistic infection, bacterial infection, or malignancy.

Required:

- Ibuprofen.

- AZT 1-2 gm daily (for study patient) or not taking AZT (for control).