The Effectiveness of Three Anti-HIV Drug Combinations in HIV-Infected Patients Who Have Never Used Anti-HIV Drugs
Status:
Completed
Trial end date:
1997-11-01
Target enrollment:
Participant gender:
Summary
To determine drug efficacy and safety in HIV-infected patients treated with zidovudine ( AZT
) versus stavudine ( d4T ) versus both drugs. Also, to compare short- and long-term changes
in magnitude of HIV RNA over time.
Asymptomatic patients with CD4 counts over 300 cells/mm3 are more likely to tolerate any of
the nucleoside analogs. d4T, with a favorable toxicity profile and demonstrated anti-HIV
activity in previous studies, provides an additional therapeutic option.
Phase:
Phase 2
Details
Lead Sponsor:
National Institute of Allergy and Infectious Diseases (NIAID)