The Effect of the GM-CSF Gel on the Endometrial Thickness in Infertile Women With Thin Endometrium

• Status: Unknown status
• Trial end date: 2020-12-01
• Target enrollment: 0
• Participant gender: Female

Summary

The purpose of this study is to investigate the efficacy of the granulocyte-macrophage colony stimulating factor(GM-CSF) gel on the endometrial thickness in infertile women with thin endometrium.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Sir Run Run Shaw Hospital
• Treatments: Estradiol; Estradiol 17 beta-cypionate; Estradiol 3-benzoate; Molgramostim; Polyestradiol phosphate; Sargramostim

Criteria

Inclusion Criteria:

1. Woman undergoes IVF treatment, 18-40 years old

2. The endometrial thickness <7mm on the day of human chorionic gonadotropin during IVF or after taking oral estradiol valerate 6mg/d for 14 days.

3. Embryo transfer is cancelled because of thin endometrium

4. No intrauterine adhesion according to the 3-D ultrasonography

Exclusion Criteria:

1. Systemic diseases unable to conceive

2. Chromasome abnormal

3. History of G-CSF or GM-CSF allergy or untoward effect

4. Thin endometrium related to clomid

5. Severe or moderate uterine adhesion

6. The influence factor of embryo implantation: hydrosalpinx, endometriosis, adenomyosis,myoma of uterus

7. Uterine malformation, adenomyosis, uterine leiomyoma sized more than 2cm.

8. Patients who is allergic to granulocyte-macrophage colony stimulating factor

9. Patients with inflammation of reproductive organs, pelvic cavity inflammation, malignant tumor of reproductive organs and other systemic diseases that could cause metrorrhagia