The Effect of the Alga Dunaliella Bardawil as a Source of 9-cis Retinoic Acid on Lipid Profile in Fibrate Treated Patients.
Status:
Completed
Trial end date:
2006-12-01
Target enrollment:
Participant gender:
Summary
The effect of fibrates on high density lipoprotein (HDL)-cholesterol levels is suggested to
be mediated by its binding to peroxisome proliferator-activated receptor-g (PPARg). Upon
ligand binding, PPARg heterodimerizes with the 9-cis retinoic acid receptor (RXR), and the
heterodimer regulates gene expression. We assessed the hypothesis that a dual treatment with
fibrate plus 9-cis b-carotene-rich powder of the alga Dunaliella bardawil, as a source of
9-cis retinoic acid, would improve the drug's effect on HDL-cholesterol levels.
patients with plasma HDL-cholesterol levels below 40 mg/dl and triglyceride (TG) levels above
200 mg/dl after fibrate treatment (for at least 6 weeks). are given four capsules of
Dunaliella, providing 60 mg b-carotene/day. The all-trans to 9-cis b-carotene ratio in the
capsules is about 1:1.