The Effect of an Antibiotic on the Production of Uremic Toxins by the Gut Microbiome

• Status: Completed
• Trial end date: 2018-08-18
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine if multiple doses of vancomycin over the course of 3 months will perturb the intestinal flora (microbiome) and result in reduced serum concentration of the uremic toxin indoxyl sulfate and p-cresyl sulfate. The design of the study will permit investigators to assess the variability of serum uremic retention solute concentrations with and without antibiotic over a three-month period.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: New York University School of Medicine; NYU Langone Health
• Treatments: Anti-Bacterial Agents; Vancomycin

Criteria

Inclusion Criteria:

• Patients with stable chronic kidney disease on hemodialysis with a fistula or an AV graft.

Exclusion Criteria:

• Antibiotics received within the last 3 months;

• recent diarrhea

• known allergy to vancomycin

• history of C. difficile infection

• elevation of white blood cell count or fever within one week of enrollment.