The Effect of a Single Dose of Lamotrigine on Brain Function in Healthy Volunteers

• Status: Completed
• Trial end date: 2019-08-30
• Target enrollment: 0
• Participant gender: All

Summary

This study will test whether a single dose of Lamotrigine (300mg) exerts significant effects on emotional processing, cognitive ability and neural activity in healthy volunteers compared to placebo.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Oxford
• Treatments: Lamotrigine

Criteria

Inclusion Criteria:

• Male or female

• Aged 18-40 years

• Willing and able to give informed consent for participation in the study

• Sufficiently fluent English to understand and complete the task

Exclusion Criteria:

• Current usage of psychoactive medication

• Current usage of the contraceptive pill

• Any past or current Axis 1 DSM-IV psychiatric disorder

• Significant medical condition

• Current pregnancy or breastfeeding

• Current or past history of drug or alcohol dependency

• Participation in a psychological or medical study involving the use of medication within the last 3 months

• Previous participation in a study using the same, or similar, emotional processing tasks

• Smoker > 5 cigarettes per day

• Typically drinks > 6 caffeinated drinks per day

• Takes folic acid supplements

• History of recurrent allergies and rashes

• Contraindication to MRI (e.g. claustrophobia and metallic implants)