The Effect of a Preoperative Single-dose Methylprednisolone on the Postoperative Rehabilitation After Abdominal Hysterectomy

• Status: Completed
• Trial end date: 2011-10-01
• Target enrollment: 0
• Participant gender: Female

Summary

The purpose of this study is to evaluate the effect of 125 mg methylprednisolone, given intravenously 60-90 minutes before abdominal surgery,on the postoperative rehabilitation after abdominal hysterectomy.Sodium Chloride is the placebo. The following parameters are registered:

1. Pain 3, 6 and 24 hours postoperatively and 2-7 days after surgery.

2. The postoperative use of additional analgesics.

3. Inflammatory parameters before and after surgery.

4. Time until mobilization.

5. Time until discharge.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Holbaek Sygehus
• Treatments: Methylprednisolone; Methylprednisolone Acetate; Methylprednisolone Hemisuccinate; Prednisolone; Prednisolone acetate; Prednisolone hemisuccinate; Prednisolone phosphate

Criteria

Inclusion Criteria:

• Patients having an abdominal hysterectomy on a benign indication.

• Patients who speak and understand Danish.

• Patients who can give informed consent.

Exclusion Criteria:

• Diabetics

• Regular use of glucocorticoids, opioids or tranquilizers

• Regular treatment with immunosuppressives

• Alcohol or drug abuse

• Morphine intolerance

• Age under 18

• Chronic pain disease eg fibromyalgia, rheumatoid arthritis

• Malign indication for hysterectomy

• BMI over 35

• Decreased kidney function

• ASA III or IV