The Effect of Vitamin D3 to Maintain Surgical Remission in Postoperative Crohn's Disease

• Status: Completed
• Trial end date: 2017-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The majority of patients with Crohn's disease (CD) need to undergo surgical bowel resection. Postoperative recurrence of the disease is virtually inevitable and continues to be one of the most challenging therapeutic problems in inflammatory bowel diseases. Medical treatments to prevent recurrence have had limited effect. Anti-tumor necrosis factor (TNF) agents appear promising but are hampered by immunogenicity, side effects and high cost.

Vitamin D has recently received a lot of scientific attention and was found to have strong anti-inflammatory and antifibrotic effects in gut and liver inflammation. Many CD patients appear to have deficiency in Vitamin D. A controlled trial to prevent relapse of CD in medical (not surgical) remission suggested a preventive effect for Vitamin D but marginally missed its endpoint because of lack of power.

The ultimate proof of the anti-inflammatory effect of Vitamin D in CD can best be studied in the prevention of postoperative recurrence.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
• Treatments: Cholecalciferol; Ergocalciferols; Vitamin D; Vitamins

Criteria

Inclusion Criteria:

• Age ≥ 18 years, either male or female

• Established CD

• First or second ileocolonic resection with ileocolonic anastomosis and removal of all tissue macroscopically affected by CD according to the surgeon

• Able to give written informed consent

• Normal levels of serum calcium at inclusion

• Being able to resume oral intake within 2 weeks after surgery

Exclusion Criteria:

• Patients in whom not all visible CD has been resected

• Active fistulizing perianal disease (requiring anti TNF treatment)

• Extensive small bowel resection

• Third, fourth or later ileocolonic resection

• Patients undergoing ileocoecal resection in the Lir!c Trial (NTR 1150, http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=1150)

• A history of primary hyperparathyroidism

• A history of osteoporosis for which calcium and Vitamin D treatment are mandatory

• A history of another granulomatous diseases (sarcoidosis, tuberculosis)

• Pregnant or breastfeeding (at index date) female patients

• Patients undergoing other resections than ileocolonic resections

• Patients who prefer to use open-label vitamin D preparations

• Patients who will continue to use tanning beds