The Effect of Vitamin D Supplementation on HIV-associated Platelet Hyperreactivity

• Status: Completed
• Trial end date: 2014-06-01
• Target enrollment: 0
• Participant gender: All

Summary

Platelets play pivotal role in atherosclerosis and acute cardiovascular events. Platelet hyperreactivity and increase platelet-monocyte aggregate (PMA) formation are found in HIV infected patients, which may contribute to the excess cardiovascular risk. Low level of vitamin D has been associated with the presence of cardiovascular diseases. The aim of our study is to determine the effect of vitamin D supplementation on platelet activation, platelet reactivity and platelet-leukocyte complex formation in asymptomatic HIV-infected patients treated with ART

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Universitas Padjadjaran
• Collaborator: Radboud University
• Treatments: Cholecalciferol; Ergocalciferols; Vitamin D; Vitamins

Criteria

Inclusion Criteria:

• >18 years

• Treated with suppressive first-line ART for at least 12 months

• Compliant to ART and procedures of Teratai clinic

• No signs or symptoms

Exclusion Criteria:

• Use of aspirin or other platelet function inhibitors.

• Any sign or symptom

• Known active opportunistic infection

• Active illicit drug users or any other comorbidity

• History of failing ART or non-compliance.

• Pregnancy