The Effect of Vericiguat on Peripheral Vascular Function, Patient Health Status and Inflammation
Status:
Not yet recruiting
Trial end date:
2025-07-30
Target enrollment:
Participant gender:
Summary
The concept that direct stimulation of soluble guanylate cyclase (sGC) could be a
particularly effective approach to increase cyclic guanosine monophosphate (cGMP) in
conditions of increased inflammation/oxidative stress, endothelial dysfunction, and reduced
nitric oxide (NO) bioavailability. Thus, the aim of the proposed study is to examine the
effect of Vericiguat on peripheral vascular function, inflammatory status, and patient health
status. The study also aims to identify patients who are particularly likely to benefit from
Vericiguat treatment and predict that these patients will be defined by baseline peripheral
vascular dysfunction and high inflammatory state.