The Effect of Varenicline on D2/D3 Receptor Binding in Smokers
Status:
Completed
Trial end date:
2015-08-01
Target enrollment:
Participant gender:
Summary
This study will evaluate effects of treatment with varenicline, a smoking cessation drug, on
the dopaminergic system by using Positron Emission Tomography (PET) imaging with new
radioligand, [11C]-(+)-PHNO. The investigators primary hypothesis is that chronic varenicline
administration will increase dopamine (DA) receptors levels ([11C](+)PHNO) within the human
brain.