The Effect of Two Aspirin Dosing Strategies for Obese Women at High Risk for Preeclampsia
Status:
Recruiting
Trial end date:
2022-01-01
Target enrollment:
Participant gender:
Summary
Low dose aspirin (LDA) is used for preeclampsia (PE) prevention in high risk women, but the
precise mechanism and optimal dose is not known. Evidence in the non-obstetric literature
suggests AR may be more common among patients with a high body mass index (BMI). Recent
unpublished data showed that LDA substantially lowers TxB2 levels regardless of BMI, but
rates of complete platelet inhibition are lower in women with BMI ≥40. This data suggests
that higher doses of ASA may be necessary in obese women. Therefore we plan determine if use
of 162mg compared to the traditional 81mg ASA decreased rates of preeclampsia in women
considered high risk for developing preclampsia.