The Effect of Treatment With Teriparatide and Zoledronic Acid in Patients With Osteogenesis Imperfecta
Status:
Terminated
Trial end date:
2021-06-01
Target enrollment:
Participant gender:
Summary
Osteogenesis imperfecta (OI) is an inherited disease of the connective tissue. Symptoms are
fractures, growth retardation, blue sclera, bad teeth, impaired hearing a.o. The aim of the
present study is to investigate the effect of treatment of adult OI patients with
bisphosphonate (zoledronic acid), parathyroid hormone (PTH) or placebo on bone mass, fracture
risk and quality of life.
The investigators will therefore conduct a double blind, placebo controlled trial, taking
genotype and previous antiresorptive therapy into account.