The Effect of Topical Imipramine on Pain and Effectiveness of Topical Photodynamic Therapy
Status:
Not yet recruiting
Trial end date:
2028-03-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is testing the use of topical Imipramine in combination with
topical photodynamic therapy's (PDT) effect on pain following treatment. PDT is a commonly
used treatment in dermatology for patients who have many pre-cancers (actinic keratosis-AKs)
on their skin. These are both FDA-approved treatments, but this study is evaluating their use
in combination, which has not been evaluated in the past. The investigators have been doing
studies using animals that suggest that imipramine might make the PDT less painful and might
help it work better. In order to participate, the subject and their dermatologist have
decided that they would benefit from PDT to treat their skin due to many AK precancerous
lesions. Please note that neither PDT nor imipramine are experimental treatments, but
treating their skin with imipramine before PDT is a new approach.