The Effect of Toothpaste Containing Aloe Vera on Gingivitis
Status:
Completed
Trial end date:
2020-11-19
Target enrollment:
Participant gender:
Summary
Twenty-four adult patients (male and female) with generalized gingivitis participated in the
double-blinded randomized crossover trial was divided into two groups, (aloe vera and Colgate
toothpaste). a week after receiving polishing and scaling,24hours plaque re-growth, one group
received Aloe Vera toothpaste twice times daily and the second group received Colgate
toothpaste twice daily. The first visit included PLI measurement after that Investigator
removed the supra gingival plaque by cotton roll to avoid contamination with the PERIOPAPER
strip during GCF collection, then GCF collected from targeted sites(upper incisors, labial
side)and Unstimulated saliva collected (for early colonizer bacterial load S. sanguinis and
S. mutant) after that the other clinical periodontal parameters ( BOP) were measured and then
scaling was done after sample collection because of gingival bleeding which occur during
scaling then inform the patient to use the coded toothpaste which gave to the participant by
the assistant not involve in the study so the researcher did not know the type of toothpaste
that was given to the participant (Colgate or aloe vera twice daily).The toothpastes was
given for one week .The codded toothpaste was gave randomly by a decision on that day for
example on Sunday Investigator gave all the participants code 1 and on other days
Investigator gave to other participants code 2 .In the second visit the PLI was measured
first , then the samples were collected from the same teeth after that the other periodontal
parameters were collected again ( BOP). After that, participants entered a 6-day wash out
period and they were asked to resume oral hygiene measures. After the washout period, the
same protocol was repeated for other type of toothpaste.