The Effect of Tongguan Capsule for MicroRNA Profiles in Coronary Heart Disease Patients

• Status: Unknown status
• Trial end date: 2017-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to test the expression of microRNAs related to the syndromes after the intervention of Tongguan capsule,preliminarily to investigate the mechanism of the effects of Tongguan capsule, and provide the biological foundation of curative effect of Tongguan capsule.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Guangdong Provincial Hospital of Traditional Chinese Medicine

Criteria

Inclusion Criteria:

1. In line with the diagnostic criteria for acute coronary syndrome (ACS), coronary angiography confirmed for coronary heart disease (CHD), parallel Percutaneous transluminal coronary angioplasty( PTCA) and/or coronary stent implantation was successful

2. Postoperative routine drug treatment

3. Traditional Chinese Medicine syndrome differentiation of qi -deficiency and qi -stagnation blood stasis or blood stasis license

4. Aged 35 to 75 years old

5. Must sign a consent form.

Exclusion Criteria:

1. Renal insufficiency, the male serum creatinine > 2.5 mg/dl (> 220 umo/l), women > 2.0 mg/dl (> 175 umo/l)

2. With obvious liver disease or Alanine aminotransferase ( ALT)， Aspartate aminotransferase ( AST), 3 times higher than normal ceiling

3. Serious cardiac insufficiency (EF < 35%)

4. Uncontrolled patients with high blood pressure

5. Merger or severe valvular heart disease in acute cerebrovascular disease

6. Random blood glucose or greater tendency for 13.7 / L diabetes or glycosylated hemoglobin 9.5% or more

7. Patients with severe mental illness

8. Patients with malignant tumor or life expectancy in less than three years

9. Patients with severe hematopoietic system disease

10. Refused to sign a consent form, or estimated compliance is poorer, follow-up possibilities claim;

11. Pregnancy or ready to pregnant women, nursing mothers;

12. Participated in nearly three months, or is in other clinical subjects . -