The Effect of Supraglottic and Oropharyngeal Decontamination on the Incidence of Ventilator-associated Pneumonia

• Status: Active, not recruiting
• Trial end date: 2021-12-31
• Target enrollment: 0
• Participant gender: All

Summary

Oropharynx is the main source of pathogen microorganisms for the ventilator - associated pneumoniae. As known bacteriophages can eliminate different pathogen microorganisms or reduce a degree of a pathogen's colonization. The research team is considering that oropharyngeal decontamination with bacteriophages can prevent the developing of the ventilator - associated pneumoniae. There will be three groups in this investigation: placebo, antiseptic drug (Octenisept) and bacteriophage (Sexthaphag).

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Northern State Medical University
• Treatments: Anti-Infective Agents, Local; Octenidine

Criteria

Inclusion Criteria:

• invasive mechanical ventilation beyond 48 hours

Exclusion Criteria:

• hospital - acquired pneumonia

• community - acquired pneumoniae

• BMI > 35 kg/cm2

• pregnancy

• tracheostomy

• reintubation