The Effect of Sulfasalazine on CRH Levels in Pregnant Women
Status:
Not yet recruiting
Trial end date:
2024-07-31
Target enrollment:
Participant gender:
Summary
The goal of this randomized clinical trial is to assess sulfasalazine as a potential
treatment to prevent recurrent preterm birth. The main questions it aims to answer are:
- Does sulfasalazine down regulate corticotropin releasing hormone (CRH) levels in
pregnant persons with a prior history of preterm birth?
- Does sulfasalazine reduce the incidence of recurrent preterm birth in pregnant persons
given drug vs. controls?
Consenting participants will be randomized to receive sulfasalazine or to a control group and
will undergo serial blood draws to assess plasma CRH levels.