The Effect of Sugammadex Versus Neostigmine on Postoperative Pulmonary Complications
Status:
Completed
Trial end date:
2018-04-30
Target enrollment:
Participant gender:
Summary
Substantial respiratory morbidity has been associated with postoperative residual paralysis,
which is fairly common after general anesthesia involving a neuromuscular blocking agent.
Common practice in United States is to reverse neuromuscular blockade with neostigmine at the
end of surgery. A new drug with evidence of more complete neuromuscular reversal has been
developed, sugammadex. The objective of this study is to determine if a strategy of
rocuronium neuromuscular reversal with sugammadex will reduce the proportion of subjects with
any postoperative pulmonary complication, compared to neostigmine.