The Effect of Some Drugs Used in Treatment of Vasculitis on the Complement System in Children
Status:
Active, not recruiting
Trial end date:
2022-05-11
Target enrollment:
Participant gender:
Summary
Vasculitis denotes affection of small to medium sized vessels by polyangitis. Antineutrophil
cytoplasmic antibodies (ANCA) are immunoglobulin G (IgG) autoantibodies directed against
constituents of neutrophil granules leading to neutrophil degeneration which results in cell
apoptosis known as "Natoptosis" (NaTosis) of the cells. These lead to vessel endothelial cell
damage. So that, ANCA formation seems to be the basic reaction in vasculitis.
Complement activation at C3 and C4 was thought to be involved in renal damage ANCA associated
vasculitis (AAV).
Phase:
Phase 3
Details
Lead Sponsor:
Assiut University
Treatments:
Complement System Proteins Ibuprofen Methotrexate Methylprednisolone Methylprednisolone Hemisuccinate Prednisone