The Effect of Sodium Nitrite on Renal Function and Blood Pressure in Healthy Humans. A Dose-response Study
Status:
Completed
Trial end date:
2014-06-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to investigate the effect of different doses of sodium nitrite
infusion in 12 healthy subjects. The effects on renal handling of nitrite, nitrate, sodium
and water, plasma concentrations of vasoactive hormones, peripheral (brachial) and central
blood pressure will be evaluated.
Hypothesis
Sodium nitrite infusion
1. increases urinary sodium excretion and renal filtration rate
2. lowers blood pressure, central as well as peripheral
3. affects vasoactive hormones
4. it is possible to establish a dose that affects the renal function with only minor
effect on the blood pressure.