The Effect of Sitagliptin on Hypertension, Arterial Stiffness, Oxidative Stress and Inflammation
Status:
Unknown status
Trial end date:
2009-06-01
Target enrollment:
Participant gender:
Summary
Recently a new category of antihyperglycemic therapy aiming to modulate the incretin system
has emerged. These drugs induce insulin secretion without inducing hypoglycemia. The effect
of the incretin modulators drugs on hypertension, arterial stiffness, inflammation and
oxidative stress parameters have not been fully investigated yet.GLP-1 analogue has been
suggested to have an effect on endothelium and the development of hypertension. Nystrom et al
have demonstrated that GLP-1 improves endothelial dysfunction in a small group of type 2
diabetes subjects, with coronary heart disease. We hypothesize that DPP-4 inhibitor will have
an effect on hypertension and arterial stiffness by effect on the NO pathway.The aim of this
study is to investigate the effect of two insulin inducers drugs, sulfonyl urea and DPP-4
inhibitor on 24 hours blood pressure monitoring, arterial stiffness, oxidative stress and
inflammation.