The Effect of Simvastatin on Desensitization of Panel-Positive Kidney Transplant Candidates

• Status: Completed
• Trial end date: 2008-05-01
• Target enrollment: 0
• Participant gender: All

Summary

Patients with panel reactive antibodies have many difficulties to find a crossmatch-negative kidney for transplantation and are at the risk of post transplantation rejection more than other transplanted patients. We evaluated the effect of simvastatin on PRA and post transplant outcome of these sensitized patients. We also performed a descriptive study.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Shiraz University of Medical Sciences
• Treatments: Simvastatin

Criteria

Inclusion Criteria:

1. patients with ESRD on hemodialysis or peritoneal dialysis

2. On the waiting list for renal transplant

3. PRA more than 25%

Exclusion Criteria:

1. Pregnant women

2. Patients who need ongoing blood products

3. Patients taking other therapies to decrease PRA

4. Patients listed for multi-organ transplant other than kidney

5. Patients with liver failure