The Effect of Serum LDL Lowering on Aspirin Resistance
Status:
Completed
Trial end date:
2007-01-01
Target enrollment:
Participant gender:
Summary
Aspirin resistance is the persistent platelet activation, demonstrated by platelet function
tests (1).
The hypothesis is that:LDL lowering by statin in patients with aspirin resistance can improve
the effect of aspirin due to the potential decreasing of cholesterol content in the platelet
membranes.
Patients and methods:Forty hypercholesterolemic patients with aspirin resistance after 5 days
of treatment with aspirin and high LDL and triglycerides<300 mg/dL, will be enrolled.
Ten healthy volunteers will be the control group.