The Effect of Sertindole on Sensory Gating and Cognition in Schizophrenic Patients
Status:
Terminated
Trial end date:
2012-08-01
Target enrollment:
Participant gender:
Summary
This study aims to investigate whether the atypical antipsychotic and mixed 5-HT2/D2
antagonist sertindole modulates or improves both subcortical and cortical information
processing in schizophrenic patients who had not or insufficiently responded to previous
antipsychotic medication. This goal shall be accomplished by investigating the effect of
sertindole of both prepulse inhibition of the acoustic startle (PPI) and P50 suppression of
auditory evoked potentials in schizophrenic patients. These effects shall be compared to the
effect of risperidone and shall also be compared to untreated healthy controls.
Phase:
N/A
Details
Lead Sponsor:
University of Zurich
Collaborators:
H. Lundbeck A/S University Hospital of Psychiatry, Department Neuropsychopharmacology and Brain Imaging