The Effect of SLC19A3 Inhibition on the Pharmacokinetics of Thiamine
Status:
Recruiting
Trial end date:
2021-12-01
Target enrollment:
Participant gender:
Summary
In Part 1, subjects will be administered thiamine, thiamine with metformin, and thiamine with
trimethoprim. Part 2 will expand on Part 1 and subjects will be administered thiamine and
thiamine with trimethoprim. The goal is to determine whether taking a drug and a vitamin
together affects the body's ability to absorb, distribute, and eliminate thiamine (Vitamin
B1).
Phase:
Phase 4
Details
Lead Sponsor:
University of California, San Francisco
Collaborators:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Tufts University University of California, Davis