The Effect of Rosuvastatin on Adenosine Metabolism

• Status: Completed
• Trial end date: 2008-04-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this study is to show whether rosuvastatin influences adenosine metabolism. Therefore we will determine whether rosuvasatin increases dipyridamole-induced vasodilation by increased adenosine receptor stimulation.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Radboud University
• Treatments: Adenosine; Dipyridamole; Rosuvastatin Calcium

Criteria

Inclusion Criteria:

• age 18 - 50 years

• Signed informed consent

Exclusion Criteria:

• hypertension

• hypercholesterolemia

• diabetes Mellitus

• alanine aminotransferase > 90 U/L

• creatinine Kinase > 440 U/L

• cardiovascular disease

• GFR < 80 ml/min