The Effect of Rikkunshito on Gastric Accommodation and Nutrient Volume Tolerance in Functional Dyspepsia
Status:
Completed
Trial end date:
2018-10-01
Target enrollment:
Participant gender:
Summary
Functional dyspepsia (FD) is a common chronic gastrointestinal (GI) disorder. Rikkunshito, a
traditional Japanese Kampo medicine, has shown efficacy in improving FD symptoms in
controlled trials in Japan. Its putative benefit for European patients has never been
investigated. Further, its exact mechanism of action is incompletely elucidated. This study
aimed to examine the effect of rikkunshito on gastric motility and GI symptom perception in
FD in a randomized, placebo-controlled, cross-over study. Intragastric pressure (IGP) was
assessed using high-resolution manometry as an indirect measurement of gastric accommodation
and gastric motility.