The Effect of Restrictive Fluid Management on Cardiac Function and Glycocalyx Degradation
Status:
Not yet recruiting
Trial end date:
2022-04-01
Target enrollment:
Participant gender:
Summary
The study aims to compare the effects of restrictive fluid management on cardiac dysfunction
and vascular integrity in septic shock patients. To achieve this, patients with septic shock
according to Sepsis-3 criteria admitted to several Intensive Care Units in Sweden and Denmark
will be randomized to receive restrictive respectively standard fluid therapy. Blood test
from these patients will be analyzed for several biomarkers of cardiac function and
glycocalyx degradation. Echocardiography will also be performed to further investigate
cardiac function.