The Effect of Propofol and Remifentanil Sequence on ED50 and ED95 of Rocuronium in Rapid Sequence Induction Anesthesia
Status:
Completed
Trial end date:
2016-04-01
Target enrollment:
Participant gender:
Summary
Rapid sequence induction (RSI) is a well-known procedure to maintain a safe and rapid airway
in patients especially at risk of aspiration. Propofol and rocuronium are generally used
agents for RSI. However, the difficult airway scenarios are always valid for these patients,
even without predictive signs of difficult airway. Therefore, it is important to decrease the
rocuronium dose used in RSI to achieve a rapid recovery of a neuromuscular conduction with
the aid of a reversal agent in case of difficult airway. The short acting opioids such as
remifentanil may be helpful to reduce the dose of rocuronium in RSI.