The Effect of Propofol Infusion on Total Antioxidant Status During Tourniquet-Induced Ischemia-Reperfusion Injury

• Status: Completed
• Trial end date: 2012-11-01
• Target enrollment: 0
• Participant gender: All

Summary

The release of tourniquet produces reactive oxygen species which can cause injury. Propofol is chemically similar to phenol-based free radical scavengers.

Plasma total antioxidant capacity is a well-established marker of the overall protective effect of antioxidants in body fluids.The aim of the study is to investigate the effects of propofol on ischemia-reperfusion injury in total knee arthroplasty (TKA).

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Diskapi Teaching and Research Hospital
• Treatments: Antioxidants; Propofol

Criteria

Inclusion Criteria:

• ASA I-II physical status

• Unilateral total knee arthroplasty

• Age 18 years to 80 years

Exclusion Criteria:

• Severe central nervous system disorders

• Severe cardiopulmonary,renal,metabolic, or hepatic disease,

• Blood volume deficits,

• Coagulopathy,

• Allergy to local anesthetics,

• Peripheral neuropathies,

• Body mass index > 35,

• History of antioxidant drug use