The Effect of Propofol Based Total Intravenous Anesthesia on Oxidative Stress and Nitric Oxide
Status:
Completed
Trial end date:
2015-02-01
Target enrollment:
Participant gender:
Summary
Robot assisted laparoscopic radical prostatectomy(Robot-LRP) requires pneumoperitoneum and
trendelenburg position which result in oxidative stress and inflammatory response.
Propofol is well known to reduce those responses during anesthesia. Therefore, we try to
figure out the efficacy of propofol to reduce oxidative stress, inflammatory response and
increase the nitric oxide activity during robot-LRP compared to that of desflurane.
To investigate the oxidative stress, malondialdehyde will be measured. As inflammatory
markers, interleukin-1β, interleukin-6, tumor necrosis factor-α will be measured. Nitric
oxide will be measured as well.
Secondarily, kidney protection effect of propofol over desflurane will be compared.