The Effect of Prophylactic Antibiotics on Surgical Site Infection Lower Limb Skin Excisions

• Status: Active, not recruiting
• Trial end date: 2023-09-01
• Target enrollment: 0
• Participant gender: All

Summary

The incidence of surgical site infection (SSI) infection in clean dermatologic surgery is very low, between 1-3%. Studies have demonstrated a much higher infection rate in skin excision surgeries in the lower limbs, up to 10% in most studies, and even 35.7% infection rate in a recent study from Australia.

To our knowledge, there are no clinical trials demonstrating the efficacy of prophylactic antibiotic given prior to skin lesion excision from the lower limbs.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Rambam Health Care Campus
• Treatments: Anti-Bacterial Agents; Antibiotics, Antitubercular; Cephalexin; Clindamycin; Clindamycin palmitate; Clindamycin phosphate

Criteria

Inclusion Criteria:

Patients presenting for skin excision from the thigh, shin or foot, in the Rambam medical center

Exclusion Criteria:

• Younger than 18 years old.

• Not capable of providing informed consent.

• Declined to participate.

• Currently taking antibiotics.

• Surgeon feels they are clinically indicated for antibiotic treatment following excision.

• Lesions considered as contaminated/ infected prior to surgery.

• Excision not utilizing primary closure or skin graft.

• Patient unable to return for suture removal.