The Effect of Prescription Medications in Marijuana Users

• Status: Completed
• Trial end date: 2011-10-01
• Target enrollment: 0
• Participant gender: All

Summary

A subset of heavy marijuana users have trouble quitting marijuana use and the number of those seeking treatment for problems related to marijuana is increasing. The purpose of this research study is to investigate whether dronabinol can reduce withdrawal effects associated with stopping marijuana use, if dronabinol can reduce the rewarding effects of smoked marijuana, and whether there are any cognitive performance deficits associated with dronabinol doses that produce such effects.

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Johns Hopkins University
• Collaborator: National Institute on Drug Abuse (NIDA)
• Treatments: Bupropion; Diazepam; Dronabinol

Criteria

Inclusion Criteria:

• current use of marijuana

• able to give informed consent

Exclusion Criteria:

• dependence on drug other than marijuana

• pregnant, breast feeding, or planning to become pregnant within the next 3 months

• currently seeking treatment for cannabis-related problems or otherwise trying to reduce use

• use of cannabis under the guidance of a physician for a medical disorder

• unstable or uncontrolled cardiovascular disease (e.g., hypertension, angina)

• allergy to study medication