The Effect of Pregabalin Given Preoperatively on the Tourniquet Induced Ischemia-reperfusion

• Status: Completed
• Trial end date: 2018-11-15
• Target enrollment: 0
• Participant gender: All

Summary

The application of tourniquet is indispensable for a bloodless surgical area in total knee arthroplasty surgery. The release of tourniquet produces reactive oxygen species which can cause injury and then ischemia-reperfusion injury emerge. Our aim in this study is to investigate effects of pregabalin, GABA analog drug, on the tourniquet induced ischemia-reperfusion injury.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Baskent University
• Treatments: Pregabalin

Criteria

Inclusion Criteria:

1. American Society of Anesthesiologists (ASA) physical status I-II

2. Undergoing a total knee arthroplasty surgery

3. Accept neuroaxial anesthesia for surgery

Exclusion Criteria:

1. Any antiepileptic drug use

2. Allergic reaction to pregabalin

3. Severe hepatic, renal or gastrointestinal disorders

4. Psychiatric disorders

5. Pregnant women or breastfeeding

6. NSAID or opioid drug use for a long time

7. Diabetic or other neuropathic pain