The Effect of Pre-treatment With GnRH Analogues Prior in Vitro Fertilization in Patients With Endometriosis

• Status: Completed
• Trial end date: 2015-05-01
• Target enrollment: 0
• Participant gender: Female

Summary

The purpose of this study is to determine whether the administration of an analogue of gonadotropin-releasing hormone (GnRH) during the three months prior to the performing of an IVF may improve the response to ovarian stimulation, implantation rate and clinical pregnancy rate in patients with endometriosis/ endometriomas.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Instituto de Investigacion Sanitaria La Fe
• Treatments: Triptorelin Pamoate

Criteria

Inclusion Criteria:

• Infertile women with endometriosis diagnosed by surgery in the previous year to their inclusion in the study with signs of residual disease and/or by the existence of ovarian endometrioma in vaginal ecography who are susceptible to IVF treatment.

• BMI < 28 Kg/m2

• Age < 40 years old

• Signed informed consent to perform IVF and participation in this study

Exclusion Criteria:

• Follicle stimulating hormone (FSH) 2nd-5th cycle day > 12 IU/L

• Liver disease (sALAT> 80 IU/L)

• Kidney disease (creatinine > 130 nmol/L)

• Other relevant disease that contraindicates a pregnancy