The Effect of Post Ablation Medroxyprogesterone Acetate on Endometrial Amenorrhea Rates
Status:
Recruiting
Trial end date:
2023-08-01
Target enrollment:
Participant gender:
Summary
Heavy menstrual bleeding are a common reason for consultation in gynecology and are defined
by International Federation of Gynecology and Obstetrics as the perception of menstrual
volume increased regardless of the frequency, duration and regularity. Some studies report
that up to 30% of women will suffer from heavy periods during their lifetime. The first line
treatment of heavy bleeding is medical. However, a significant proportion of women require
surgery. Until the 80s, hysterectomy was one of the only surgical options and often performed
as the first line treatment. Since twenty years now the endometrial ablation has become a
preferred option for dysfunctional uterine bleeding and avoids hysterectomy in a significant
proportion of patients suffering from this type of problem. Endometrial ablation is much less
invasive and morbid than hysterectomy, however, many patients do not achieve a complete
amenorrhea with endometrial ablation and about 15% may have to require a new intervention,
such as hysterectomy, following the persistence of menstrual problems. A Cochrane review
published in 2013 showed that the satisfaction rate following endometrial ablation is high at
70-80% and about 35% of women have amenorrhea. The complete destruction of the endometrium is
the most important predictor of the success of the procedure. Studies have shown that better
results are obtained when the surgery is performed when the endometrium is thin or
immediately following menses or following administration of a hormonal agent causes atrophy
of the endometrium. One of the agents studied to prepare the endometrium before ablation is
medroxyprogesterone acetate (MPA) as injectables (DMPA) and oral. Progestins have an
antiproliferative effect on the endometrium. In recent years, numerous studies have examined
the use of various agents preoperatively, including MPA and DMPA to facilitate surgery by
reducing the thickness of the endometrium. However, few studies have focused on the
conditions of the post-operative period to promote the therapeutic response to the
intervention. The investigators hypothesis is whether the MPA administered in immediate
post-operative would inhibit proliferation of endometrial cells responsible for the
persistence of menstruation and optimize the clinical response to endometrial ablation.