The Effect of Perioperative Intravenous Lidocaine Infusion on Opioid Consumption After Lumbar Spine Surgery

• Status: Unknown status
• Trial end date: 2020-06-09
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether an infusion of lidocaine during surgery can reduce the need for postoperative opioid pain medication use in patients undergoing lumbar spine surgery.

Participants will be recruited by spine surgeons from their pool of patients who are presenting for surgery at University of Vermont Medical Center. If they agree to participate, patients will be assigned at random to receive either an infusion of lidocaine during surgery, or an infusion of saline with 5% dextrose. Subjects will also be asked to complete a 15-item questionnaire that asks about health, quality of life, and level of pain, at three timepoints. Patients will also be asked to rate their level of pain at multiple timepoints after surgery, and we will collect the additionally data from patients' medical records.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Vermont Medical Center
• Treatments: Analgesics, Opioid; Lidocaine

Criteria

Inclusion Criteria:

• Patient undergoing one- or two-level posterior lumbar fusion with or without decompression at University of Vermont Medical Center

• 18-75 years of age

• Signed consent form

Exclusion Criteria:

• Allergy to lidocaine

• Contraindication to lidocaine, such as substantial hepatic impairment (alanine aminotransferase or aspartate transaminase more than twice normal), renal impairment (serum creatinine >2 mg/dl)

• Seizures or a history of seizure disorder

• Congestive heart failure

• Arrythmias

• Chronic opioid use >45 mg morphine equivalent per day

• Trauma patients

• Inter-body fusions

• Severe psychiatric comorbidities

• Planned epidural anesthesia or analgesia